Antimalarial efficacy of piperaquine-based antimalarial combination therapies: facts and uncertainties
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چکیده
منابع مشابه
Fixed Dose Combination of Arterolane and Piperaquine: A Newer Prospect in Antimalarial Therapy
Malaria has been very prevalent vector-borne disease in India and until date bears enormous implications on health care services of the country. Over the period of time, the development of resistance to traditional antimalarials like chloroquine has been posed as major deterrent in efforts of malaria control. As the drug resistance is today universally prevalent, especially in Plasmodium falcip...
متن کاملClinical Pharmacology of the Antimalarial Artemisinin-Based Combination and other Artemisinins in Children
In 2010, there were estimated 219 million cases of malaria resulting in 666,000 deaths and two-thirds were children. Children are more vulnerable than adults to malaria parasites. In sub-Saharan African countries, maternal malaria is associated with up to 200,000 estimated infant deaths yearly. Malaria is caused by five Plasmodium parasites namely: Plasmodium falciparum, Plasmodium vivax, Plasm...
متن کاملPharmacokinetics of the antimalarial drug piperaquine in healthy Vietnamese subjects.
We compared plasma maximum concentration (Cmax) and area under the concentration-time curve (AUC) of the antimalarial drug piperaquine in 26 healthy Vietnamese subjects after treatment with either a single oral dose of 500 mg (n = 6) or 1,000 mg (n = 6) of piperaquine phosphate and a three-day course of 500 mg of piperaquine/ day in the fasting state (n = 7) or with food (approximately 17 g fat...
متن کاملCharacterization of human urinary metabolites of the antimalarial piperaquine.
Five metabolites of the antimalarial piperaquine (PQ) (1,3-bis-[4-(7-chloroquinolyl-4)-piperazinyl-1]-propane) have been identified and their molecular structures characterized. After a p.o. dose of dihydroartemisinin-piperaquine, urine collected over 16 h from two healthy subjects was analyzed using liquid chromatography (LC)/UV, LC/tandem mass spectrometry (MS/MS), Fourier transform ion cyclo...
متن کاملHigh Antimalarial Efficacy of Dihydroartemisinin–Piperaquine on the China–Myanmar Border: The Calm before the Storm
Dihydroartemisinin–piperaquine (DP) is the frontline artemisinin combination therapy (ACT) for uncomplicated falciparum malaria in several areas of southeast Asia, including Cambodia, Vietnam, and the China–Myanmar border. In this issue, Wang and others report that the clinical antimalarial efficacy of DP in northeastern Myanmar’s Kachin State, near its border with China, was 100% in 2012–2013....
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ژورنال
عنوان ژورنال: Tropical Medicine & International Health
سال: 2011
ISSN: 1360-2276
DOI: 10.1111/j.1365-3156.2011.02855.x